GC MS/MS
GC MS
Advanced Molecular Analysis
Gas Chromatography with Tandem Mass Spectrometry (GC-MS/MS) enables the precise identification and quantification of organic compounds at trace levels. This powerful technique is ideal for analyzing complex mixtures, offering unparalleled sensitivity and selectivity through the use of multiple reaction monitoring (MRM).
GC-MS/MS is widely regarded as the gold standard for analyzing volatile and semi-volatile organic compounds. The instrumentation we use provides exceptional performance, delivering high-resolution mass spectra and accurate quantification across a broad dynamic range. For targeted analysis, this technique can isolate specific molecular ions and provide detailed structural information, making it an indispensable tool for advanced molecular investigations.

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To deliver the highest precision and selectivity for trace organic compound analysis, Artemis Labs utilizes state-of-the-art Gas Chromatography with Tandem Mass Spectrometry (GC-MS/MS) technology. Our approach is tailored to handle complex matrices, ensuring reliable identification and quantification of even the most challenging analytes.
All our analytical methods undergo rigorous validation for accuracy, precision, linearity, sensitivity, specificity, limit of detection (LOD), limit of quantitation (LOQ), and robustness. We are committed to reporting results with clarity and reliability, ensuring that every assay achieves quantification at levels well below regulatory thresholds, with routine assays exceeding twice the LOQ for unparalleled confidence.
How Does GC MS/MS Work?
Gas Chromatography with Tandem Mass Spectrometry (GC-MS/MS) is a sophisticated analytical technique that combines gas chromatography’s separation capabilities with the powerful molecular identification and quantification provided by tandem mass spectrometry. This technique is particularly well-suited for analyzing volatile and semi-volatile organic compounds in complex matrices, offering exceptional sensitivity and specificity.
The process begins with sample preparation, where the target compounds are extracted and, if necessary, concentrated to optimize detection. The prepared sample is then introduced into the gas chromatograph through an injection port, where it is vaporized and carried by an inert gas, typically helium, into the chromatographic column. The column is coated with a stationary phase that interacts with the sample components, separating them based on their volatility and chemical properties as they travel through the column.
Once separated, the individual compounds exit the column and enter the mass spectrometer. In the first stage, they are ionized, typically using electron impact (EI) ionization, which fragments the molecules into charged ions. These ions are then filtered and directed into the first quadrupole (or mass analyzer), which selects specific precursor ions based on their mass-to-charge ratio. The selected precursor ions are subjected to collision-induced dissociation (CID) in a collision cell, where they collide with neutral gas molecules, breaking into distinct fragment ions. These fragment ions are then passed to the second quadrupole, which analyzes them based on their mass-to-charge ratios. This tandem setup allows for precise identification and quantification of target analytes by their unique fragmentation patterns.
GC-MS/MS’s strength lies in its ability to isolate and analyze specific compounds even in the presence of complex matrices or interfering substances. The high sensitivity enables detection at trace levels, while the tandem mass spectrometry provides enhanced selectivity, making it an essential tool for fields such as environmental analysis, food safety, pharmaceutical research, and forensic investigations. Additionally, the technique supports both qualitative and quantitative analysis, offering a comprehensive view of the sample’s composition. Automated software and advanced calibration methods ensure reliable and reproducible results, while features like multiple reaction monitoring (MRM) enable simultaneous analysis of multiple target compounds with exceptional accuracy.
By leveraging the precision of gas chromatography and the analytical power of tandem mass spectrometry, GC-MS/MS delivers unparalleled performance for complex molecular analyses, solidifying its place as a cornerstone of modern analytical science.
Additional GC MS Information
What makes GC-MS a powerful tool for compound analysis?
Gas Chromatography-Mass Spectrometry (GC-MS) is a cornerstone analytical technique due to its ability to separate, identify, and quantify compounds with high precision. By combining gas chromatography, which separates complex mixtures into individual components, with mass spectrometry, which provides molecular-level identification, GC-MS excels in handling challenging samples.
Its sensitivity allows for the detection of trace levels of analytes, and its specificity ensures accurate compound identification through retention times and mass spectra. This dual capability makes GC-MS indispensable for applications such as environmental analysis, forensic investigations, and pharmaceutical quality control.
What types of samples can be analyzed using GC-MS?
GC-MS is highly versatile and can analyze a wide variety of sample types, including environmental samples, biological samples, and complex mixtures. It is commonly used for analyzing volatile and semi-volatile organic compounds, such as those found in environmental analysis, forensic science, and pharmaceutical research. Sample preparation is crucial to ensure the analytes are in a suitable state for gas chromatography and mass spectrometry analysis.
What role does sample preparation play in GC-MS analysis?
Proper sample preparation is critical in GC-MS analysis to ensure accurate results. It involves steps like extraction, concentration, and purification of analytes from the sample matrix. This process reduces interference from other components and ensures efficient transfer of the sample into the GC-MS instrument. For example, in environmental analysis, preparing complex samples like water or soil ensures that target compounds can be detected and quantified effectively.
How does GC-MS ensure accurate identification of compounds?
GC-MS achieves precise compound identification by combining the separation power of gas chromatography with the molecular identification capabilities of mass spectrometry. Retention times from the GC column, along with unique mass spectra, enable accurate identification of known compounds and components within the sample. Quantitative analysis is performed by measuring peak areas and comparing them to standards, ensuring reliable results even in complex mixtures.
What are the advantages of GC-MS compared to other techniques?
GC-MS offers unmatched sensitivity, selectivity, and versatility, especially for the analysis of volatile compounds. Unlike liquid chromatography, which is more suited for non-volatile analytes, gas chromatography excels in separating compounds with lower boiling points. Additionally, the mass spectrometry component provides unparalleled compound identification, making GC-MS a preferred analytical technique for many industries.
What industries rely on GC-MS, and for what applications?
GC-MS is widely used in numerous industries due to its analytical power. In environmental analysis, it helps identify pollutants in air, water, and soil. In the pharmaceutical industry, it ensures the purity of compounds and aids in drug development. Forensic science uses GC-MS for compound identification in biological samples, while the food industry employs it for quality control and contamination analysis. These applications highlight the versatility of gas chromatography-mass spectrometry.
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